{"id":9633,"date":"2023-10-12T12:00:47","date_gmt":"2023-10-12T12:00:47","guid":{"rendered":"https:\/\/wiserootz.nl\/?p=9633"},"modified":"2026-09-16T12:34:30","modified_gmt":"2026-09-16T10:34:30","slug":"lions-mane-brain","status":"publish","type":"post","link":"https:\/\/wiserootz.nl\/en\/lions-mane-hersenen\/","title":{"rendered":"Lion\u2019s Mane: Effects and Benefits for the Brain"},"content":{"rendered":"

Lion\u2019s Mane (Hericium erinaceus<\/em>), known in the Netherlands as the \u2018wig mushroom\u2019, is a remarkable mushroom that is attracting increasing attention in research into the brain, concentration and cognitive health. It is particularly the bioactive compounds hericenones and erinacines that make Lion\u2019s Mane of interest to scientists.<\/strong><\/p>\n\n\n\n

From memory and concentration to nerve growth factors and neuroplasticity: what makes Lion\u2019s Mane so interesting for the brain?<\/p>\n\n\n\n

What is Lion\u2019s Mane?<\/h2>\n\n\n\n

Lion\u2019s Mane is instantly recognisable by its long, white spines, which are reminiscent of a lion\u2019s mane.<\/p>\n\n\n\n

This mushroom has long been eaten and used in traditional Asian medicine. These days, it is attracting particular attention for its unique bioactive compounds.<\/p>\n\n\n\n

These include hericenones and erinacines<\/strong>.<\/p>\n\n\n\n

Preclinical research suggests that certain compounds found in Lion\u2019s Mane may influence processes involved in Nerve Growth Factor (NGF)<\/strong> and the development and maintenance of nerve cells. NGF plays an important role within the nervous system and is involved, amongst other things, in the growth, maintenance and plasticity of certain neurons. <\/p>\n\n\n\n

That is one of the main reasons why Lion\u2019s Mane is currently attracting so much interest in brain research.<\/p>\n\n\n\n

Lion\u2019s Mane and the brain: what do we know?<\/h2>\n\n\n\n

Lion\u2019s Mane is attracting a great deal of attention, particularly due to the possible link between its bioactive compounds and processes in the brain. In particular, hericenones and erinacines<\/strong> are being investigated for their potential impact on Nerve Growth Factor (NGF), nerve cells and neuroplasticity.<\/p>\n\n\n\n

This makes Lion\u2019s Mane an interesting subject for research into, amongst other things, cognition, memory, attention and the nervous system. The scientific evidence base is growing, with mechanistic and preclinical research in particular having expanded significantly, whilst the number of human studies is also increasing.<\/p>\n\n\n\n

It is precisely this combination of traditional use and modern neuroscience that makes Lion\u2019s Mane one of the most extensively researched functional mushrooms in the field of brain health and cognitive function.<\/p>\n\n\n\n

1. Lion\u2019s Mane and cognitive function<\/h2>\n\n\n\n

One of the key areas of research into Lion\u2019s Mane is its potential link to cognitive function and the brain.<\/p>\n\n\n\n

And there are now human studies on this as well.<\/p>\n\n\n\n

In a double-blind, placebo-controlled study involving older adults with mild cognitive impairment, improvements on a cognitive scale were observed whilst taking Lion\u2019s Mane. <\/p>\n\n\n\n

Another randomised study investigated 12 weeks\u2019 use of Lion\u2019s Mane and also found evidence of improvement in certain cognitive functions. <\/p>\n\n\n\n

Interestingly, Lion\u2019s Mane is now also being studied in younger, healthy adults.<\/p>\n\n\n\n

A small double-blind pilot study conducted in 2023 found improved performance on a cognitive task after a single dose and a trend towards reduced stress levels after 28 days. The researchers do, however, emphasise that this was a small study. <\/p>\n\n\n\n

So the overall picture is interesting: Cognition is one of the key areas in which Lion\u2019s Mane is currently being researched.<\/strong><\/p>\n\n\n\n

\"Lion\u2019s<\/figure>\n\n\n\n

2. Lion\u2019s Mane: focus and concentration<\/h2>\n\n\n\n

Cognitive performance, of course, involves much more than just memory.<\/p>\n\n\n\n

Attention, reaction speed, information processing and the ability to stay focused are all part of how we use our brains on a daily basis.<\/p>\n\n\n\n

Would you like to gain a better understanding of how attention works, why our focus wanders and what happens when we switch between tasks? Then read Focus: Why Your Attention Doesn\u2019t Always Do What You Want<\/strong>.<\/a><\/p>\n\n\n\n

Research is also being carried out into this.<\/p>\n\n\n\n

A clinical study into various natural extracts found that Lion\u2019s Mane led to improvements in measures including working memory, complex attention and reaction time. <\/p>\n\n\n\n

It should be noted, however, that not every study finds the same effects. For example, a recent double-blind study from 2025 found no general acute improvement in cognition or mood, although better performance was observed on one specific motor task. <\/p>\n\n\n\n

That is precisely what makes Lion\u2019s Mane an interesting subject for further research: the effects may well depend on extract, duration of use, target group and the specific cognitive domain<\/strong>.<\/p>\n\n\n\n

Focus and cognitive flexibility also play a role in creative processes. You may also wish to read our in-depth article on Microdosing and creativity.<\/a><\/p>\n\n\n\n

3. Lion\u2019s Mane and neuroplasticity<\/h2>\n\n\n\n

Perhaps the most fascinating area of research into Lion\u2019s Mane is its relationship with the nervous system.<\/p>\n\n\n\n

Our brains are not static.<\/p>\n\n\n\n

They are able to adapt to new information and experiences throughout our lives. We call this ability neuroplasticity<\/strong>.<\/p>\n\n\n\n

NGF and other neurotrophic factors play an important role in this. They are involved in processes such as neuronal development, synaptic transmission, learning and plasticity. <\/p>\n\n\n\n

Bioactive compounds from Lion\u2019s Mane are being investigated in preclinical studies because of their potential influence on such neurotrophic processes.<\/p>\n\n\n\n

This raises an interesting research question:<\/p>\n\n\n\n

That is why scientists are investigating whether Lion\u2019s Mane might influence the processes involved in the brain\u2019s ability to adapt.<\/strong><\/p>\n\n\n\n

There is still much to discover about it, but it is one of the reasons why Lion\u2019s Mane holds such a special place amongst medicinal mushrooms.<\/p>\n\n\n\n

4. Lion\u2019s Mane and the nervous system<\/h2>\n\n\n\n

Lion\u2019s Mane is not only being studied for its effects on cognitive function.<\/p>\n\n\n\n

The potential impact on nerve cells and neurite growth<\/strong> has attracted a great deal of scientific interest.<\/p>\n\n\n\n

Laboratory and animal studies have identified effects on, amongst other things, NGF synthesis, neurite growth, neuro-inflammatory processes and various mechanisms involved in nerve health. <\/p>\n\n\n\n

This is promising fundamental research.<\/p>\n\n\n\n

However, this does not mean that Lion\u2019s Mane simply \u201crepairs\u201d damaged nerves in humans. Much of this mechanistic research is still at the pre-clinical stage.<\/p>\n\n\n\n

5. Lion\u2019s Mane and mental balance<\/h2>\n\n\n\n

Another interesting area of research is mood and stress<\/strong>.<\/p>\n\n\n\n

A small placebo-controlled study involving 30 women found that, after four weeks of taking Lion\u2019s Mane, there were changes in questionnaire scores relating to, amongst other things, mood and certain subjective symptoms. <\/p>\n\n\n\n

In the aforementioned pilot study involving healthy young adults, a trend towards reduced subjective stress was also observed after 28 days. <\/p>\n\n\n\n

This field of research is still in its infancy, but it shows that scientists are looking beyond just memory and concentration.<\/p>\n\n\n\n

\"Lion\u2019s<\/figure>\n\n\n\n

What does the research as a whole tell us?<\/h2>\n\n\n\n

Lion\u2019s Mane is more than just a popular wellness trend: research into the mushroom has now been carried out in both human and pre-clinical studies.<\/p>\n\n\n\n

At the same time, the human trials are still relatively small.<\/p>\n\n\n\n

A systematic review from 2025 brought together five randomised controlled trials, three clinical pilot studies and several preclinical studies. The results show promising indications regarding cognitive functions, but also confirm that further well-designed human studies are needed. <\/p>\n\n\n\n

A previous review of human studies on mushrooms and neurocognition reached a similar conclusion: Lion\u2019s Mane, in particular, showed promising results for mood and cognitive function, but the findings from intervention studies were not all consistent. <\/p>\n\n\n\n

For us, that\u2019s precisely what makes Lion\u2019s Mane so interesting:<\/p>\n\n\n\n

a traditional mushroom, the bioactive compounds of which modern science is increasingly seeking to understand in terms of their effects on the body.<\/strong><\/p>\n\n\n\n

Lion\u2019s Mane at Wise Rootz<\/h2>\n\n\n\n

Because of this special relationship with cognition and the nervous system, Lion\u2019s Mane has a special place within Wise Rootz.<\/p>\n\n\n\n

You can find Lion\u2019s Mane in our Focus Force tincture<\/strong>, in which we combine various botanical extracts and functional mushrooms within a single, targeted formula.<\/p>\n\n\n\n

In addition, Lion\u2019s Mane is part of the Full Focus Microdosing Box<\/strong>.<\/p>\n\n\n\n

In that respect, the mushroom fits in well with our broader philosophy: not searching for a single magic ingredient, but consciously looking at routine, focus, reflection and the elements that form part of such a ritual<\/strong>.<\/p>\n\n\n\n

Discover Focus Force \u2192<\/a><\/strong><\/p>\n\n\n\n

Discover the Full Focus Microdosing Box<\/a> \u2192<\/strong><\/p>\n\n\n\n

Frequently asked questions about Lion\u2019s Mane and the brain<\/h2>\n\n\n\n

What effect does Lion\u2019s Mane have on the brain?<\/strong><\/h3>\n\n\n\n


Lion\u2019s Mane is particularly interesting because of bioactive compounds such as hericenones and erinacines. These are being studied in relation to Nerve Growth Factor (NGF), nerve cells and cognitive processes. It is precisely this combination that makes Lion\u2019s Mane one of the most interesting functional mushrooms in modern brain research.<\/p>\n\n\n\n

Is Lion\u2019s Mane good for memory and concentration?<\/strong><\/h3>\n\n\n\n


There have been human studies in which positive changes have been observed in certain cognitive measures, including aspects of memory, attention and reaction time. The results are promising, but have not yet been consistent across all studies. As a result, Lion\u2019s Mane remains primarily an interesting ingredient within a broader approach to focus and lifestyle.<\/p>\n\n\n\n

What are hericenones and erinacines?<\/strong><\/h3>\n\n\n\n


Hericenones and erinacines are characteristic bioactive compounds found in Lion\u2019s Mane. They are the subject of considerable scientific interest due to their potential link to NGF and processes relating to nerve cells and neuroplasticity.<\/p>\n\n\n\n

Has the effectiveness of Lion\u2019s Mane been scientifically proven?<\/strong><\/h3>\n\n\n\n


There is now both human and preclinical research into Lion\u2019s Mane, with interesting findings regarding cognition, nerve cells and mental balance. The scientific evidence base is growing, but the research is still relatively new and larger human studies are needed to further substantiate the findings.<\/p>\n\n\n\n

A special mushroom for a special organ<\/h2>\n\n\n\n

Your brain continues to adapt throughout your life.<\/p>\n\n\n\n

That is precisely why the research into Lion\u2019s Mane is so interesting.<\/p>\n\n\n\n

From hericenones and erinacines to NGF, cognition and neuroplasticity: modern science is gaining an ever-better understanding of why this ancient mushroom is attracting so much interest.<\/p>\n\n\n\n

For us, Lion\u2019s Mane is therefore more than just a trend.<\/p>\n\n\n\n

It is one of the most interesting edible mushrooms at the intersection of nature, cognition and modern neuroscience<\/strong>.<\/p>\n\n\n\n

Disclaimer<\/h3>\n\n\n\n

This blog is intended to provide general, educational information about Lion\u2019s Mane and scientific research, and does not constitute medical advice. Dietary supplements and botanical extracts are not a substitute for a varied diet, a healthy lifestyle or medical treatment. Are you taking any medication, are you pregnant or breastfeeding, or do you have a medical condition? If so, please discuss the use of supplements or concentrated extracts with a doctor or other qualified healthcare professional beforehand.<\/p>\n\n\n\n

Sources<\/h3>\n\n\n\n

Scientific Sources<\/p>\n\n\n\n

Ma B-J, Shen J-W, Yu H-Y, Ruan Y, Wu T-T, Zhao X.<\/strong> Hericenones and erinacines: stimulators of nerve growth factor (NGF) biosynthesis in Hericium erinaceus<\/em>. Mycology.<\/em> 2010;1(2):92\u201398. doi:10.1080\/21501201003735556. <\/p>\n\n\n\n

Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T.<\/strong> The health benefits of the Yamabushitake mushroom (Hericium erinaceus<\/em>) on mild cognitive impairment: a double-blind, placebo-controlled clinical trial. Phytotherapy Research.<\/em>2009;23(3):367\u2013372. doi:10.1002\/ptr.2634. <\/p>\n\n\n\n

Saitsu Y, Nishide A, Kikushima K, Shimizu K, Ohnuki K.<\/strong> Improvement in cognitive function following oral intake of Hericium erinaceus<\/em>. Biomedical Research.<\/em> 2019;40(4):125\u2013131. doi:10.2220\/biomedres.40.125. <\/p>\n\n\n\n

Docherty S, Doughty FL, Smith EF.<\/strong> The Acute and Chronic Effects of Lion\u2019s Mane Mushroom Supplementation on Cognitive Function, Stress and Mood in Young Adults: A Double-Blind, Parallel-Group Pilot Study. Nutrients.<\/em>2023;15(22):4842. doi:10.3390\/nu15224842. <\/p>\n\n\n\n

Surendran G, Saye J, Binti Mohd Jalil S, Spreadborough J, Duong K, Shatwan IM, Lilley D, Heinrich M, Dodd GF, Surendran S.<\/strong> Acute effects of a standardised extract of Hericium erinaceus<\/em> (Lion\u2019s Mane mushroom) on cognition and mood in healthy younger adults: a double-blind, randomised, placebo-controlled study. Frontiers in Nutrition.<\/em> 2025;12:1405796. doi:10.3389\/fnut.2025.1405796. <\/p>\n\n\n\n

Nagano M, Shimizu K, Kondo R, Hayashi C, Sato D, Kitagawa K, Ohnuki K.<\/strong> Reduction in depression and anxiety within 4 weeks Hericium erinaceus<\/em> intake. Biomedical Research.<\/em> 2010;31(4):231\u2013237. doi:10.2220\/biomedres.31.231. <\/p>\n\n\n\n

Cha S, Bell L, Shukitt-Hale B, Williams CM.<\/strong> A review of the effects of mushrooms on mood and neurocognitive health throughout the lifespan. Neuroscience & Biobehavioural Reviews.<\/em> 2024;158:105548. doi:10.1016\/j.neubiorev.2024.105548. <\/p>\n\n\n\n

Menon A, Jalal A, Arshad Z, Nawaz FA, Kashyap R.<\/strong> Benefits, side effects and uses of Hericium erinaceus<\/em> as a supplement: a systematic review. Frontiers in Nutrition.<\/em> 2025;12:1641246. doi:10.3389\/fnut.2025.1641246. <\/p>","protected":false},"excerpt":{"rendered":"

Lion\u2019s Mane (Hericium erinaceus), in Nederland bekend als pruikzwam, is een bijzondere paddenstoel die steeds meer aandacht krijgt binnen onderzoek naar hersenen, focus en cognitieve gezondheid. Vooral de bioactieve stoffen hericenonen en erinacines maken Lion\u2019s Mane interessant voor wetenschappers. Van geheugen en concentratie tot zenuwgroeifactoren en neuroplasticiteit: wat maakt Lion\u2019s Mane zo interessant voor het […]<\/p>\n","protected":false},"author":1,"featured_media":13922,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[73,69],"tags":[],"class_list":["post-9633","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-adaptogenen","category-wetenschap"],"acf":[],"yoast_head":"\nLion\u2019s Mane werking en voordelen voor de hersenen<\/title>\n<meta name=\"description\" content=\"Ontdek de werking van Lion\u2019s Mane en wat onderzoek zegt over 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