{"id":10583,"date":"2024-01-15T16:47:13","date_gmt":"2024-01-15T15:47:13","guid":{"rendered":"https:\/\/wiserootz.nl\/?page_id=10583"},"modified":"2026-08-27T10:54:16","modified_gmt":"2026-08-27T08:54:16","slug":"sources","status":"publish","type":"page","link":"https:\/\/wiserootz.nl\/en\/bronnen\/","title":{"rendered":"Sources"},"content":{"rendered":"\t\t
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Wetenschappelijke bronnen<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Bij Wise Rootz vinden we het belangrijk dat informatie over cacao, botanicals, functionele paddenstoelen, psilocybine en microdosing<\/strong> zorgvuldig wordt onderbouwd.<\/p>

Voor onze educatieve content raadplegen we peer-reviewed wetenschappelijke literatuur, waaronder systematische reviews, meta-analyses, gerandomiseerde klinische onderzoeken en, waar relevant, mechanistisch en preklinisch onderzoek. Daarnaast gebruiken we offici\u00eble bronnen van onder andere de European Food Safety Authority (EFSA), European Medicines Agency (EMA), Europese Commissie en NVWA<\/strong>.<\/p>

Wetenschappelijke kennis ontwikkelt zich voortdurend. Daarom bekijken en actualiseren we onze bronnenbibliotheek wanneer nieuwe relevante inzichten beschikbaar komen.<\/p>

Over de interpretatie van onderzoek<\/strong>
Dat een ingredi\u00ebnt of stof wetenschappelijk is onderzocht, betekent niet automatisch dat de resultaten gelden voor ieder extract, iedere dosering of ieder Wise Rootz-product. Wetenschappelijke onderbouwing en wettelijk toegestane gezondheidsclaims zijn bovendien twee verschillende zaken. Voor communicatie over levensmiddelen en voedingssupplementen gelden Europese regels voor voedings- en gezondheidsclaims; medische claims zijn daarbij niet toegestaan.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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1. Cacao & cacaoflavanolen <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/i><\/span>\n\t\t\t<\/i><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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Cacaoflavanolen & vaatfunctie<\/h3>

Sun Y, Zimmermann D, De Castro CA, Actis-Goretta L. (2019).<\/strong>
Dose-response relationship between cocoa flavanols and human endothelial function: a systematic review and meta-analysis of randomized trials.<\/em>
Food & Function, 10<\/em>(10), 6322\u20136330.
doi:10.1039\/C9FO01747J.
Bekijk op PubMed<\/a><\/span><\/span><\/p>

Lin X, Zhang I, Li A, et al. (2016).<\/strong>
Cocoa Flavanol Intake and Biomarkers for Cardiometabolic Health: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.<\/em>
The Journal of Nutrition, 146<\/em>(11), 2325\u20132333.
doi:10.3945\/jn.116.237644.
Bekijk op PubMed<\/a><\/span><\/span><\/p>

Sesso HD, Manson JE, Aragaki AK, et al. (2022).<\/strong>
Effect of cocoa flavanol supplementation for the prevention of cardiovascular disease events: the COcoa Supplement and Multivitamin Outcomes Study (COSMOS) randomized clinical trial.<\/em>
The American Journal of Clinical Nutrition, 115<\/em>(6), 1490\u20131500.
doi:10.1093\/ajcn\/nqac055.
Bekijk op PubMed<\/a><\/span><\/span><\/p>

Cacao & cognitieve functie<\/h3>

Desideri G, Kwik-Uribe C, Grassi D, et al. (2012).<\/strong>
Benefits in cognitive function, blood pressure, and insulin resistance through cocoa flavanol consumption in elderly subjects with mild cognitive impairment: the Cocoa, Cognition, and Aging (CoCoA) study.<\/em>
Hypertension, 60<\/em>(3), 794\u2013801.
doi:10.1161\/HYPERTENSIONAHA.112.193060.
Bekijk op PubMed<\/a><\/span><\/span><\/p>

Socci V, Tempesta D, Desideri G, De Gennaro L, Ferrara M. (2017).<\/strong>
Enhancing Human Cognition with Cocoa Flavonoids.<\/em>
Frontiers in Nutrition, 4<\/em>, 19.
doi:10.3389\/fnut.2017.00019.
Bekijk op PubMed<\/a><\/span><\/span><\/p>

Cacao & cerebrale doorbloeding<\/h3>

Fisher NDL, Sorond FA, Hollenberg NK. (2006).<\/strong>
Cocoa flavanols and brain perfusion.<\/em>
Journal of Cardiovascular Pharmacology, 47 Suppl 2<\/em>, S210\u2013S214.
doi:10.1097\/00005344-200606001-00017.
Bekijk op PubMed<\/a><\/span><\/span><\/p>

Francis ST, Head K, Morris PG, Macdonald IA. (2006).<\/strong>
The effect of flavanol-rich cocoa on the fMRI response to a cognitive task in healthy young people.<\/em>
Journal of Cardiovascular Pharmacology, 47 Suppl 2<\/em>, S215\u2013S220.
doi:10.1097\/00005344-200606001-00018.
Bekijk op PubMed<\/a><\/span><\/span><\/p>

Cacao & darmmicrobioom<\/h3>

Sorrenti V, Ali S, Mancin L, Davinelli S, Paoli A, Scapagnini G. (2020).<\/strong>
Cocoa Polyphenols and Gut Microbiota Interplay: Bioavailability, Prebiotic Effect, and Impact on Human Health.<\/em>
Nutrients, 12<\/em>(7), 1908.
doi:10.3390\/nu12071908.
Bekijk op PubMed<\/a><\/span><\/span><\/p>

Cacao & huid<\/h3>

Yoon HS, Kim JR, Park GY, et al. (2016).<\/strong>
Cocoa Flavanol Supplementation Influences Skin Conditions of Photo-Aged Women: A 24-Week Double-Blind, Randomized, Controlled Trial.<\/em>
The Journal of Nutrition, 146<\/em>(1), 46\u201350.
doi:10.3945\/jn.115.217711.
Bekijk op PubMed<\/a><\/span><\/span><\/p>

Cacaoflavanolen \u2014 offici\u00eble Europese beoordeling<\/h3>

EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA). (2012).<\/strong>
Scientific Opinion on the substantiation of a health claim related to cocoa flavanols and maintenance of normal endothelium-dependent vasodilation pursuant to Article 13(5) of Regulation (EC) No 1924\/2006.<\/em>
EFSA Journal, 10<\/em>(7), 2809.
doi:10.2903\/j.efsa.2012.2809.
Bekijk bij EFSA<\/a><\/span><\/span><\/p>

Cacaoboter & vetzuursamenstelling<\/h3>

Shahkhalili Y, Duruz E, Acheson K. (2000).<\/strong>
Digestibility of cocoa butter from chocolate in humans: a comparison with corn-oil.<\/em>
European Journal of Clinical Nutrition, 54<\/em>, 120\u2013125.<\/p>

Bekijk op PubMed<\/a><\/span><\/span><\/p>

Denke MA, Grundy SM. (1991).<\/strong>
Effects of fats high in stearic acid on lipid and lipoprotein concentrations in men.<\/em>
The American Journal of Clinical Nutrition, 54<\/em>(6), 1036\u20131040.
doi:10.1093\/ajcn\/54.6.1036.<\/p>

Bekijk op PubMed<\/a><\/span><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t

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2. Psilocybine & microdosing <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/i><\/span>\n\t\t\t<\/i><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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Microdosing<\/h3>

Polito V, Liknaitzky P. (2022).<\/strong>
The emerging science of microdosing: A systematic review of research on low dose psychedelics (1955\u20132021) and recommendations for the field.<\/em>
Neuroscience & Biobehavioral Reviews, 139<\/em>, 104706.
doi:10.1016\/j.neubiorev.2022.104706.
Bekijk op PubMed<\/a><\/span><\/span><\/p>

Kuypers KPC, Ng L, Erritzoe D, Knudsen GM, Nichols CD, Nichols DE, Pani L, Soula A, Nutt D. (2019).<\/strong>
Microdosing psychedelics: More questions than answers? An overview and suggestions for future research.<\/em>
Journal of Psychopharmacology, 33<\/em>(9), 1039\u20131057.
doi:10.1177\/0269881119857204.
Bekijk op PubMed<\/a><\/span><\/span><\/p>

Placebo-gecontroleerd microdosingonderzoek<\/h3>

Cavanna F, Muller S, de la Fuente LA, et al. (2022).<\/strong>
Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study.<\/em>
Translational Psychiatry, 12<\/em>, 307.
Bekijk op PubMed<\/a><\/span><\/span><\/p>

Fadiman & microdosingpraktijk<\/h3>

Fadiman J, Korb S. (2019).<\/strong>
Might Microdosing Psychedelics Be Safe and Beneficial? An Initial Exploration.<\/em>
Journal of Psychoactive Drugs, 51<\/em>(2), 118\u2013122.
doi:10.1080\/02791072.2019.1593561.
Bekijk op PubMed<\/a><\/span><\/span><\/p>

Psilocybine \u2014 farmacologie & werkingsmechanisme<\/h3>

Tyl\u0161 F, P\u00e1len\u00ed\u010dek T, Hor\u00e1\u010dek J. (2014).<\/strong>
Psilocybin \u2014 Summary of knowledge and new perspectives.<\/em>
European Neuropsychopharmacology, 24<\/em>(3), 342\u2013356.
doi:10.1016\/j.euroneuro.2013.12.006.
Bekijk op PubMed<\/a><\/span><\/span><\/p>

Psilocybin in neuropsychiatry: a review of its pharmacology, safety, and efficacy. (2022).<\/strong>
Review van de farmacologie van psilocybine en psilocine, waaronder de rol van serotonerge receptoren en in het bijzonder 5-HT2A.
Bekijk op PubMed<\/a><\/span><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t

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3. Microdosing & ADHD <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/i><\/span>\n\t\t\t<\/i><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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Microdosing bij volwassenen met ADHD<\/h3>

Haijen ECHM, Hurks PPM, Kuypers KPC. (2022).<\/strong>
Microdosing with psychedelics to self-medicate for ADHD symptoms in adults: A prospective naturalistic study.<\/em>
Neuroscience Applied, 1<\/em>, 101012.
doi:10.1016\/j.nsa.2022.101012.
Bekijk op PubMed<\/a><\/span><\/span><\/p>

Haijen ECHM, Hurks PPM, Kuypers KPC. (2023).<\/strong>
Trait mindfulness and personality characteristics in a microdosing ADHD sample: a naturalistic prospective survey study.<\/em>
Frontiers in Psychiatry, 14<\/em>, 1233585.
doi:10.3389\/fpsyt.2023.1233585.
Bekijk op PubMed<\/a><\/span><\/span><\/p>

Haijen ECHM, Hurks PPM, Kuypers KPC. (2024).<\/strong>
Effects of psychedelic microdosing versus conventional ADHD medication use on emotion regulation, empathy, and ADHD symptoms in adults with severe ADHD symptoms: A naturalistic prospective comparison study.<\/em>
European Psychiatry, 67<\/em>(1), e18.
doi:10.1192\/j.eurpsy.2024.8.
Bekijk op PubMed<\/a><\/span><\/span><\/p>

Gerandomiseerd gecontroleerd onderzoek<\/h3>

Mueller L, Santos de Jesus J, Schmid Y, et al. (2025).<\/strong>
Safety and Efficacy of Repeated Low-Dose LSD for ADHD Treatment in Adults: A Randomized Clinical Trial.<\/em>
JAMA Psychiatry, 82<\/em>(6), 555\u2013562.
doi:10.1001\/jamapsychiatry.2025.0044.
Bekijk op PubMed<\/a><\/span><\/span><\/p>

\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t

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4. Psychedelica, menstruatiecyclus & vrouwelijke hormonen <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/i><\/span>\n\t\t\t<\/i><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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Psychedelica & vrouwelijke hormonen<\/h3>

Kuypers KPC, Mason NL, Carlier A, Totomanova I, Haijen-Bongers ECHM. (2026).<\/strong>
Psychedelics and women’s mental health: the effects of female sex hormones on psychedelics’ efficacy and tolerability.<\/em>
Molecular Psychiatry.<\/em>
doi:10.1038\/s41380-026-03801-2.
Bekijk op PubMed<\/a><\/span><\/span><\/p>

Psychedelica & menstruatiecyclus<\/h3>

Gukasyan N, Narayan SK. (2024).<\/strong>
Menstrual Changes and Reversal of Amenorrhea Induced by Classic Psychedelics: A Case Series.<\/em>
Journal of Psychoactive Drugs, 56<\/em>(1), 50\u201355.
doi:10.1080\/02791072.2022.2157350.
Bekijk op PubMed<\/a><\/span><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t

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5. Veiligheid, medicatie & interacties <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/i><\/span>\n\t\t\t<\/i><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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Veiligheid van microdosing<\/h3>

Modzelewski S, Stankiewicz A, Waszkiewicz N, \u0141ukasiewicz K. (2025).<\/strong>
Side effects of microdosing lysergic acid diethylamide and psilocybin: A systematic review of potential physiological and psychiatric outcomes.<\/em>
Neuropharmacology, 271<\/em>, 110402.
doi:10.1016\/j.neuropharm.2025.110402.
Bekijk op PubMed<\/a><\/span><\/span><\/p>

Veiligheid van psilocybine<\/h3>

Yerubandi A, Thomas JE, Bhuiya NMA, et al. (2024).<\/strong>
Acute Adverse Effects of Therapeutic Doses of Psilocybin: A Systematic Review and Meta-Analysis.<\/em>
JAMA Network Open, 7<\/em>(4), e245960.
doi:10.1001\/jamanetworkopen.2024.5960.
Bekijk op PubMed<\/a><\/span><\/span><\/p>

Psilocybine & geneesmiddelinteracties<\/h3>

Sarparast A, Thomas K, Malcolm B, Stauffer CS. (2022).<\/strong>
Drug-drug interactions between psychiatric medications and MDMA or psilocybin: a systematic review.<\/em>
Psychopharmacology, 239<\/em>(6), 1945\u20131976.
doi:10.1007\/s00213-022-06083-y.
Bekijk op PubMed<\/a><\/span><\/span><\/p>

Lithium & klassieke psychedelica<\/h3>

Nayak SM, Gukasyan N, Barrett FS, Erowid E, Erowid F, Griffiths RR. (2021).<\/strong>
Classic Psychedelic Coadministration with Lithium, but Not Lamotrigine, is Associated with Seizures: An Analysis of Online Psychedelic Experience Reports.<\/em>
Pharmacopsychiatry, 54<\/em>(5), 240\u2013245.
doi:10.1055\/a-1524-2794.
Bekijk op PubMed<\/a><\/span><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t

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6. Functionele paddenstoelen <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/i><\/span>\n\t\t\t<\/i><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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Lion\u2019s Mane \u2014 Hericium erinaceus<\/em><\/span><\/h3>

Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. (2009).<\/strong>
Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial.<\/em>
Phytotherapy Research, 23<\/em>(3), 367\u2013372.
doi:10.1002\/ptr.2634.<\/p>

Bekijk op PubMed<\/a><\/span><\/span><\/p>

Saitsu Y, et al. (2019).<\/strong>
Improvement of cognitive functions by oral intake of Hericium erinaceus.<\/em>
Biomedical Research, 40<\/em>(4), 125\u2013131.<\/p>

Bekijk op PubMed<\/a><\/span><\/span><\/p>

Cordyceps<\/h3>

Dewi L, Khemtong C. (2025).<\/strong>
Ergogenic Aid by Cordyceps: Does It Work?<\/em>
Current Nutrition Reports, 14<\/em>(1), 97.
doi:10.1007\/s13668-025-00690-9.<\/p>

Bekijk op PubMed<\/a><\/span><\/span><\/p>

Reishi \u2014 Ganoderma lucidum<\/em><\/span><\/h3>

The Nutritional Significance of Ganoderma lucidum on Human Health: A GRADE-Assessed Systematic Review and Meta-Analysis of Clinical Trials. (2025).<\/strong><\/p>

Bekijk op PubMed<\/a><\/span><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t

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7. Botanicals & bioactieve stoffen <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/i><\/span>\n\t\t\t<\/i><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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Astaxanthine<\/h3>

Zhou X, Cao Q, Orfila C, Zhao J, Zhang L. (2021).<\/strong>
Systematic Review and Meta-Analysis on the Effects of Astaxanthin on Human Skin Ageing.<\/em>
Nutrients, 13<\/em>(9), 2917.
doi:10.3390\/nu13092917.
Bekijk op PubMed<\/a><\/span><\/span><\/p>

Bacopa monnieri<\/h3>

Kongkeaw C, Dilokthornsakul P, Thanarangsarit P, Limpeanchob N, Scholfield CN. (2014).<\/strong>
Meta-analysis of randomized controlled trials on cognitive effects of Bacopa monnieri extract.<\/em>
Journal of Ethnopharmacology, 151<\/em>(1), 528\u2013535.
doi:10.1016\/j.jep.2013.11.008.
Bekijk op PubMed<\/a><\/span><\/span><\/p>

Citroenmelisse \u2014 Melissa officinalis<\/em><\/span><\/h3>

Ghazizadeh J, Sadigh-Eteghad S, Marx W, et al. (2021).<\/strong>
The effects of lemon balm (Melissa officinalis L.) on depression and anxiety in clinical trials: A systematic review and meta-analysis.<\/em>
Phytotherapy Research, 35<\/em>(12), 6690\u20136705.
doi:10.1002\/ptr.7252.
Bekijk op PubMed<\/a><\/span><\/span><\/p>

Curcuma \u2014 Curcuma longa<\/em><\/span><\/h3>

Hewlings SJ, Kalman DS. (2017).<\/strong>
Curcumin: A Review of Its Effects on Human Health.<\/em>
Foods, 6<\/em>(10), 92.
doi:10.3390\/foods6100092.
Bekijk op PubMed<\/a><\/span><\/span><\/p>

Devil\u2019s Claw \u2014 Harpagophytum procumbens \/ Harpagophytum zeyheri<\/em><\/span><\/h3>

European Medicines Agency (EMA).<\/strong>
European Union herbal monograph on Harpagophytum procumbens DC. and\/or Harpagophytum zeyheri Decne., radix.<\/em>
EMA\/HMPC\/627057\/2015.
Bekijk bij EMA<\/a><\/span><\/span><\/p>

Ginkgo biloba<\/h3>

Hort J, Duning T, Hoerr R. (2023).<\/strong>
Ginkgo biloba Extract EGb 761 in the Treatment of Patients with Mild Neurocognitive Impairment: A Systematic Review.<\/em>
Neuropsychiatric Disease and Treatment, 19<\/em>, 647\u2013660.
doi:10.2147\/NDT.S401905.
Bekijk op PubMed<\/a><\/span><\/span><\/p>

European Medicines Agency (EMA).<\/strong>
European Union herbal monograph on Ginkgo biloba L., folium.<\/em>
Bekijk bij EMA<\/a><\/span><\/span><\/p>

Gotu Kola \u2014 Centella asiatica<\/em><\/span><\/h3>

Puttarak P, Dilokthornsakul P, Saokaew S, et al. (2017).<\/strong>
Effects of Centella asiatica (L.) Urb. on cognitive function and mood related outcomes: A Systematic Review and Meta-analysis.<\/em>
Scientific Reports, 7<\/em>, 10646.
doi:10.1038\/s41598-017-09823-9.
Bekijk op PubMed<\/a><\/span><\/span><\/p>

Groene thee \u2014 Camellia sinensis<\/em><\/span><\/h3>

Mancini E, Beglinger C, Drewe J, Zanchi D, Lang UE, Borgwardt S. (2017).<\/strong>
Green tea effects on cognition, mood and human brain function: A systematic review.<\/em>
Phytomedicine, 34<\/em>, 26\u201337.
doi:10.1016\/j.phymed.2017.07.008.
Bekijk op PubMed<\/a><\/span><\/span><\/p>

Guarana \u2014 Paullinia cupana<\/em><\/span><\/h3>

Hack B, Penna EM, Talik T, Chandrashekhar R, Millard-Stafford M. (2023).<\/strong>
Effect of Guarana (Paullinia cupana) on Cognitive Performance: A Systematic Review and Meta-Analysis.<\/em>
Nutrients, 15<\/em>(2), 434.
doi:10.3390\/nu15020434.
Bekijk op PubMed<\/a><\/span><\/span><\/p>

Guayusa \u2014 Ilex guayusa<\/em><\/span><\/h3>

Krieger DR, Kalman DS, Feldman S, et al. (2016).<\/strong>
The Safety, Pharmacokinetics, and Nervous System Effects of Two Natural Sources of Caffeine in Healthy Adult Males.<\/em>
Clinical and Translational Science, 9<\/em>(5), 246\u2013251.
doi:10.1111\/cts.12403.
Bekijk op PubMed<\/a><\/span><\/span><\/p>

Wise G, Negrin A. (2020).<\/strong>
A critical review of the composition and history of safe use of guayusa: a stimulant and antioxidant novel food.<\/em>
Critical Reviews in Food Science and Nutrition, 60<\/em>(14), 2393\u20132404.
doi:10.1080\/10408398.2019.1643286.
Bekijk op PubMed<\/a><\/span><\/span><\/p>

Kaneel \u2014 Cinnamomum<\/em> spp.<\/span><\/h3>

Sarmadi B, Musazadeh V, Dehghan P, Karimi E. (2023).<\/strong>
The effect of cinnamon consumption on lipid profile, oxidative stress, and inflammation biomarkers in adults: An umbrella meta-analysis of randomized controlled trials.<\/em>
Nutrition, Metabolism and Cardiovascular Diseases, 33<\/em>(10), 1821\u20131835.
doi:10.1016\/j.numecd.2023.03.010.
Bekijk op PubMed<\/a><\/span><\/span><\/p>

Mucuna \u2014 Mucuna pruriens<\/em><\/span><\/h3>

Mucuna pruriens Treatment for Parkinson Disease: A Systematic Review of Clinical Trials. (2025).<\/strong>
Systematische review van klinisch onderzoek naar Mucuna pruriens<\/em>.
Bekijk op PubMed<\/a><\/span><\/span><\/p>

NMN \u2014 nicotinamide mononucleotide<\/h3>

Song Q, Zhou X, Xu K, et al. (2023).<\/strong>
The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update.<\/em>
Advances in Nutrition, 14<\/em>(6), 1416\u20131435.
doi:10.1016\/j.advnut.2023.08.008.
Bekijk op PubMed<\/a><\/span><\/span><\/p>

Panax ginseng<\/h3>

Geng J, Dong J, Ni H, et al. (2010).<\/strong>
Ginseng for cognition.<\/em>
Cochrane Database of Systematic Reviews<\/em>, Issue 12, CD007769.
doi:10.1002\/14651858.CD007769.pub2.
Bekijk op PubMed<\/a><\/span><\/span><\/p>

Papayablad \u2014 Carica papaya<\/em><\/span><\/h3>

Lim XY, Chan JSW, Japri N, Lee JC, Tan TYC. (2021).<\/strong>
Carica papaya L. Leaf: A Systematic Scoping Review on Biological Safety and Herb-Drug Interactions.<\/em>
Evidence-Based Complementary and Alternative Medicine, 2021<\/em>, 5511221.
doi:10.1155\/2021\/5511221.
Bekijk op PubMed<\/a><\/span><\/span><\/p>

Passiebloem \u2014 Passiflora incarnata<\/em><\/span><\/h3>

Janda K, Wojtkowska K, Jakubczyk K, Antoniewicz J, Skonieczna-\u017bydecka K. (2020).<\/strong>
Passiflora incarnata in Neuropsychiatric Disorders\u2014A Systematic Review.<\/em>
Nutrients, 12<\/em>(12), 3894.
doi:10.3390\/nu12123894.
Bekijk op PubMed<\/a><\/span><\/span><\/p>

European Medicines Agency (EMA).<\/strong>
European Union herbal monograph on Passiflora incarnata L., herba.<\/em>
Bekijk bij EMA<\/a><\/span><\/span><\/p>

Resveratrol<\/h3>

Berman AY, et al. (2024).<\/strong>
Resveratrol for the Management of Human Health: How Far Have We Come? A Systematic Review of Resveratrol Clinical Trials to Highlight Gaps and Opportunities.<\/em>
Systematische review van humane klinische studies naar resveratrol.
Bekijk op PubMed<\/a><\/span><\/span><\/p>

Rhodiola rosea<\/h3>

Ishaque S, Shamseer L, Bukutu C, Vohra S. (2012).<\/strong>
Rhodiola rosea for physical and mental fatigue: a systematic review.<\/em>
BMC Complementary and Alternative Medicine, 12<\/em>, 70.
doi:10.1186\/1472-6882-12-70.
Bekijk op PubMed<\/a><\/span><\/span><\/p>

Saffraan \u2014 Crocus sativus<\/em><\/span><\/h3>

Mahmoudi R, Mohammadi-Sartang M, Servatyari K, Rafieipour N. (2026).<\/strong>
Effect of saffron on depression, anxiety and mood disorder: a GRADE assessed systematic review and meta-analysis of 34 randomized controlled trials.<\/em>
Nutritional Neuroscience, 29<\/em>(7), 816\u2013837.
doi:10.1080\/1028415X.2025.2602153.
Bekijk op PubMed<\/a><\/span><\/span><\/p>

Mohammadi MM, Karimi Z. (2026).<\/strong>
Effect of saffron on premenstrual syndrome and dysmenorrhea: a systematic review and meta-analysis.<\/em>
Korean Journal of Family Medicine, 47<\/em>(1), 69\u201380.
doi:10.4082\/kjfm.24.0259.
Bekijk op PubMed<\/a><\/span><\/span><\/p>

Valeriaan \u2014 Valeriana officinalis<\/em><\/span><\/h3>

European Medicines Agency (EMA).<\/strong>
European Union herbal monograph on Valeriana officinalis L., radix.<\/em>
Bekijk bij EMA<\/a><\/span><\/span><\/p>

Wilgenbast \u2014 Salix<\/em> spp.<\/span><\/h3>

European Medicines Agency (EMA).<\/strong>
European Union herbal monograph on Salix [various species including S. purpurea L., S. daphnoides Vill., S. fragilis L.], cortex.<\/em>
EMA\/HMPC\/80630\/2016.
Bekijk bij EMA<\/a><\/span><\/span><\/p>

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8. Tincturen, extracten & standaardisatie <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/i><\/span>\n\t\t\t<\/i><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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Onderzoek naar botanicals is niet automatisch toepasbaar op ieder product dat dezelfde plant bevat. De samenstelling van een botanisch extract wordt onder andere be\u00efnvloed door de gebruikte plantensoort, het plantdeel, de extractiemethode, het extractiemiddel, de extractverhouding en eventuele standaardisatie op specifieke inhoudsstoffen<\/strong>.<\/p>

Daarom kijken we bij het beoordelen van wetenschappelijke literatuur niet alleen naar de naam van een plant, maar ook naar de specifieke bereiding die in het onderzoek is gebruikt.<\/p>

Kwaliteit van botanische preparaten<\/h3>

European Medicines Agency (EMA).<\/strong>
Guideline on quality of herbal medicinal products\/traditional herbal medicinal products.<\/em><\/p>

Europese richtlijn voor onder andere de identificatie, productie, karakterisering en kwaliteitscontrole van plantaardige stoffen en bereidingen.<\/p>

Bekijk bij EMA<\/a><\/span><\/span><\/p>

Declaratie van botanische extracten<\/h3>

European Medicines Agency (EMA).<\/strong>
Guideline on declaration of herbal substances and herbal preparations in herbal medicinal products\/traditional herbal medicinal products.<\/em><\/p>

Europese richtlijn voor de beschrijving en declaratie van plantaardige stoffen en preparaten, waaronder extracten.<\/p>

Bekijk bij EMA<\/a><\/span><\/span><\/p>

European Pharmacopoeia<\/h3>

European Directorate for the Quality of Medicines & HealthCare (EDQM).<\/strong>
European Pharmacopoeia.<\/em><\/p>

De Europese Farmacopee bevat offici\u00eble kwaliteitsstandaarden en monografie\u00ebn voor onder andere plantaardige grondstoffen, extracten en andere botanische preparaten.<\/p>

Bekijk de European Pharmacopoeia bij EDQM<\/a><\/span><\/span><\/p>

Europese kruidenmonografie\u00ebn<\/h3>

European Medicines Agency (EMA) \u2014 Committee on Herbal Medicinal Products (HMPC).<\/strong>
European Union herbal monographs.<\/em><\/p>

Wetenschappelijke monografie\u00ebn waarin per botanical onder andere de botanische identiteit, gebruikte plantdelen, preparaten en beschikbare wetenschappelijke gegevens worden beoordeeld.<\/p>

Bekijk Herbal Medicines bij EMA<\/a><\/span><\/span><\/p>

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9. Offici\u00eble & regelgevende bronnen <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/i><\/span>\n\t\t\t<\/i><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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Niet iedere wetenschappelijke publicatie heeft dezelfde bewijskracht. Bij Wise Rootz kijken we daarom niet alleen \u00f3f er onderzoek naar een ingredi\u00ebnt bestaat<\/strong>, maar ook naar het type onderzoek, de kwaliteit van de studie en de mate waarin de resultaten relevant zijn voor de informatie die we delen.<\/p>

Waar mogelijk geven we prioriteit aan:<\/p>

Systematische reviews en meta-analyses<\/strong>
Onderzoeken waarin de resultaten van meerdere relevante studies gezamenlijk worden beoordeeld.<\/p>

Gerandomiseerde gecontroleerde onderzoeken (RCT\u2019s)<\/strong>
Humane studies waarin een interventie onder gecontroleerde omstandigheden wordt vergeleken met een controle- of placebogroep.<\/p>

Overig humaan onderzoek<\/strong>
Zoals observationele, prospectieve en farmacokinetische studies.<\/p>

Preklinisch en mechanistisch onderzoek<\/strong>
Laboratorium- en dieronderzoek dat kan bijdragen aan het begrijpen van biologische mechanismen, maar waarvan de resultaten niet automatisch naar mensen kunnen worden vertaald.<\/p>

Van ingredi\u00ebnt naar eindproduct<\/h3>

Ook de onderzochte vorm is belangrijk. Resultaten uit onderzoek naar een specifieke stof, plant of gestandaardiseerd extract zijn niet automatisch toepasbaar op ieder product waarin dat ingredi\u00ebnt voorkomt.<\/p>

Daarom kijken we onder andere naar de gebruikte botanische soort, het plantdeel, extracttype, standaardisatie, dosering en onderzoeksduur<\/strong>.<\/p>

Wetenschap blijft in ontwikkeling<\/h3>

Wetenschappelijke kennis is voortdurend in beweging. Nieuwe studies kunnen bestaande inzichten versterken, nuanceren of veranderen. Daarom bekijken en actualiseren we onze bronnen en educatieve content periodiek wanneer daar aanleiding toe is.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Deze bronnenbibliotheek is bedoeld als transparant overzicht van de wetenschappelijke en offici\u00eble bronnen achter onze educatieve content. Het is geen medisch advies en de vermelding van onderzoek naar een ingredi\u00ebnt betekent niet dat een Wise Rootz-product bedoeld is om een ziekte te voorkomen, behandelen of genezen.<\/p>

Laatst inhoudelijk herzien: augustus 2026.<\/strong><\/p>

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Wetenschappelijke bronnen Bij Wise Rootz vinden we het belangrijk dat informatie over cacao, botanicals, functionele paddenstoelen, psilocybine en microdosing zorgvuldig wordt onderbouwd. Voor onze educatieve content raadplegen we peer-reviewed wetenschappelijke literatuur, waaronder systematische reviews, meta-analyses, gerandomiseerde klinische onderzoeken en, waar relevant, mechanistisch en preklinisch onderzoek. Daarnaast gebruiken we offici\u00eble bronnen van onder andere de European […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-10583","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nWetenschappelijke bronnen | Wise Rootz<\/title>\n<meta name=\"description\" content=\"Wetenschappelijke bronnen over cacao, botanicals, functionele paddenstoelen, psilocybine en microdosing bij Wise Rootz.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/wiserootz.nl\/en\/sources\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Bronnen\" \/>\n<meta property=\"og:description\" content=\"Wetenschappelijke bronnen over cacao, botanicals, functionele paddenstoelen, psilocybine en microdosing bij Wise Rootz.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/wiserootz.nl\/en\/sources\/\" \/>\n<meta property=\"og:site_name\" content=\"Wise Rootz\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.instagram.com\/wiserootz.nl\/\" \/>\n<meta property=\"article:modified_time\" content=\"2026-08-27T08:54:16+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"25 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/wiserootz.nl\\\/bronnen\\\/\",\"url\":\"https:\\\/\\\/wiserootz.nl\\\/bronnen\\\/\",\"name\":\"Wetenschappelijke bronnen | Wise Rootz\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/wiserootz.nl\\\/#website\"},\"datePublished\":\"2024-01-15T15:47:13+00:00\",\"dateModified\":\"2026-08-27T08:54:16+00:00\",\"description\":\"Wetenschappelijke bronnen over cacao, botanicals, functionele paddenstoelen, psilocybine en microdosing bij Wise Rootz.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/wiserootz.nl\\\/bronnen\\\/#breadcrumb\"},\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/wiserootz.nl\\\/bronnen\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/wiserootz.nl\\\/bronnen\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/wiserootz.nl\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Bronnen\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/wiserootz.nl\\\/#website\",\"url\":\"https:\\\/\\\/wiserootz.nl\\\/\",\"name\":\"Wise Rootz\",\"description\":\"Live better. 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